Carboptic
Brand names,
Carboptic
Analogs
Carboptic
Brand Names Mixture
Carboptic
Chemical_Formula
C6H15N2O2+
Carboptic
RX_link
http://www.rxlist.com/cgi/generic2/carbachol.htm
Carboptic
fda sheet
Carboptic
msds (material safety sheet)
Carboptic
Synthesis Reference
No information avaliable
Carboptic
Molecular Weight
147.196 g/mol
Carboptic
Melting Point
210 oC
Carboptic
H2O Solubility
1 g/ml
Carboptic
State
Solid
Carboptic
LogP
-3.78
Carboptic
Dosage Forms
Liquid; Solution; Tablet
Carboptic
Indication
Primarily used in the treatment of glaucoma, but is also used during ophthalmic surgery.
Carboptic
Pharmacology
Carbachol is a potent cholinergic (parasympathomimetic) agent which produces constriction of the iris and ciliary body resulting in reduction in intraocular pressure. The exact mechanism by which carbachol lowers intraocular pressure is not precisely known. In the cat and rat, carbachol is well-known for its ability to induce rapid eye movement (REM) sleep when microinjected into the pontine reticular formation. Carbachol elicits this REM sleep-like state via activation of postsynaptic muscarinic cholinergic receptors (mAChRs).
Carboptic
Absorption
Not well absorbed in the gastro-intestinal tract, and does not cross the blood-brain barrier.
Carboptic
side effects and Toxicity
Oral, mouse: LD50 = 15 mg/kg; Oral, rat: LD50 = 40 mg/kg.
Carboptic
Patient Information
No information avaliable
Carboptic
Organisms Affected
Humans and other mammals