Carbamylcholine chloride
Brand names,
Carbamylcholine chloride
Analogs
Carbamylcholine chloride
Brand Names Mixture
Carbamylcholine chloride
Chemical_Formula
C6H15N2O2+
Carbamylcholine chloride
RX_link
http://www.rxlist.com/cgi/generic2/carbachol.htm
Carbamylcholine chloride
fda sheet
Carbamylcholine chloride
msds (material safety sheet)
Carbamylcholine chloride
Synthesis Reference
No information avaliable
Carbamylcholine chloride
Molecular Weight
147.196 g/mol
Carbamylcholine chloride
Melting Point
210 oC
Carbamylcholine chloride
H2O Solubility
1 g/ml
Carbamylcholine chloride
State
Solid
Carbamylcholine chloride
LogP
-3.78
Carbamylcholine chloride
Dosage Forms
Liquid; Solution; Tablet
Carbamylcholine chloride
Indication
Primarily used in the treatment of glaucoma, but is also used during ophthalmic surgery.
Carbamylcholine chloride
Pharmacology
Carbachol is a potent cholinergic (parasympathomimetic) agent which produces constriction of the iris and ciliary body resulting in reduction in intraocular pressure. The exact mechanism by which carbachol lowers intraocular pressure is not precisely known. In the cat and rat, carbachol is well-known for its ability to induce rapid eye movement (REM) sleep when microinjected into the pontine reticular formation. Carbachol elicits this REM sleep-like state via activation of postsynaptic muscarinic cholinergic receptors (mAChRs).
Carbamylcholine chloride
Absorption
Not well absorbed in the gastro-intestinal tract, and does not cross the blood-brain barrier.
Carbamylcholine chloride
side effects and Toxicity
Oral, mouse: LD50 = 15 mg/kg; Oral, rat: LD50 = 40 mg/kg.
Carbamylcholine chloride
Patient Information
No information avaliable
Carbamylcholine chloride
Organisms Affected
Humans and other mammals