Choline chlorine carbamate
Brand names,
Choline chlorine carbamate
Analogs
Choline chlorine carbamate
Brand Names Mixture
Choline chlorine carbamate
Chemical_Formula
C6H15N2O2+
Choline chlorine carbamate
RX_link
http://www.rxlist.com/cgi/generic2/carbachol.htm
Choline chlorine carbamate
fda sheet
Choline chlorine carbamate
msds (material safety sheet)
Choline chlorine carbamate
Synthesis Reference
No information avaliable
Choline chlorine carbamate
Molecular Weight
147.196 g/mol
Choline chlorine carbamate
Melting Point
210 oC
Choline chlorine carbamate
H2O Solubility
1 g/ml
Choline chlorine carbamate
State
Solid
Choline chlorine carbamate
LogP
-3.78
Choline chlorine carbamate
Dosage Forms
Liquid; Solution; Tablet
Choline chlorine carbamate
Indication
Primarily used in the treatment of glaucoma, but is also used during ophthalmic surgery.
Choline chlorine carbamate
Pharmacology
Carbachol is a potent cholinergic (parasympathomimetic) agent which produces constriction of the iris and ciliary body resulting in reduction in intraocular pressure. The exact mechanism by which carbachol lowers intraocular pressure is not precisely known. In the cat and rat, carbachol is well-known for its ability to induce rapid eye movement (REM) sleep when microinjected into the pontine reticular formation. Carbachol elicits this REM sleep-like state via activation of postsynaptic muscarinic cholinergic receptors (mAChRs).
Choline chlorine carbamate
Absorption
Not well absorbed in the gastro-intestinal tract, and does not cross the blood-brain barrier.
Choline chlorine carbamate
side effects and Toxicity
Oral, mouse: LD50 = 15 mg/kg; Oral, rat: LD50 = 40 mg/kg.
Choline chlorine carbamate
Patient Information
No information avaliable
Choline chlorine carbamate
Organisms Affected
Humans and other mammals