Lentine
Brand names,
Lentine
Analogs
Lentine
Brand Names Mixture
Lentine
Chemical_Formula
C6H15N2O2+
Lentine
RX_link
http://www.rxlist.com/cgi/generic2/carbachol.htm
Lentine
fda sheet
Lentine
msds (material safety sheet)
Lentine
Synthesis Reference
No information avaliable
Lentine
Molecular Weight
147.196 g/mol
Lentine
Melting Point
210 oC
Lentine
H2O Solubility
1 g/ml
Lentine
State
Solid
Lentine
LogP
-3.78
Lentine
Dosage Forms
Liquid; Solution; Tablet
Lentine
Indication
Primarily used in the treatment of glaucoma, but is also used during ophthalmic surgery.
Lentine
Pharmacology
Carbachol is a potent cholinergic (parasympathomimetic) agent which produces constriction of the iris and ciliary body resulting in reduction in intraocular pressure. The exact mechanism by which carbachol lowers intraocular pressure is not precisely known. In the cat and rat, carbachol is well-known for its ability to induce rapid eye movement (REM) sleep when microinjected into the pontine reticular formation. Carbachol elicits this REM sleep-like state via activation of postsynaptic muscarinic cholinergic receptors (mAChRs).
Lentine
Absorption
Not well absorbed in the gastro-intestinal tract, and does not cross the blood-brain barrier.
Lentine
side effects and Toxicity
Oral, mouse: LD50 = 15 mg/kg; Oral, rat: LD50 = 40 mg/kg.
Lentine
Patient Information
No information avaliable
Lentine
Organisms Affected
Humans and other mammals