Karbamoylcholin chlorid
Brand names,
Karbamoylcholin chlorid
Analogs
Karbamoylcholin chlorid
Brand Names Mixture
Karbamoylcholin chlorid
Chemical_Formula
C6H15N2O2+
Karbamoylcholin chlorid
RX_link
http://www.rxlist.com/cgi/generic2/carbachol.htm
Karbamoylcholin chlorid
fda sheet
Karbamoylcholin chlorid
msds (material safety sheet)
Karbamoylcholin chlorid
Synthesis Reference
No information avaliable
Karbamoylcholin chlorid
Molecular Weight
147.196 g/mol
Karbamoylcholin chlorid
Melting Point
210 oC
Karbamoylcholin chlorid
H2O Solubility
1 g/ml
Karbamoylcholin chlorid
State
Solid
Karbamoylcholin chlorid
LogP
-3.78
Karbamoylcholin chlorid
Dosage Forms
Liquid; Solution; Tablet
Karbamoylcholin chlorid
Indication
Primarily used in the treatment of glaucoma, but is also used during ophthalmic surgery.
Karbamoylcholin chlorid
Pharmacology
Carbachol is a potent cholinergic (parasympathomimetic) agent which produces constriction of the iris and ciliary body resulting in reduction in intraocular pressure. The exact mechanism by which carbachol lowers intraocular pressure is not precisely known. In the cat and rat, carbachol is well-known for its ability to induce rapid eye movement (REM) sleep when microinjected into the pontine reticular formation. Carbachol elicits this REM sleep-like state via activation of postsynaptic muscarinic cholinergic receptors (mAChRs).
Karbamoylcholin chlorid
Absorption
Not well absorbed in the gastro-intestinal tract, and does not cross the blood-brain barrier.
Karbamoylcholin chlorid
side effects and Toxicity
Oral, mouse: LD50 = 15 mg/kg; Oral, rat: LD50 = 40 mg/kg.
Karbamoylcholin chlorid
Patient Information
No information avaliable
Karbamoylcholin chlorid
Organisms Affected
Humans and other mammals