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Tocainide Brand names, Tocainide Analogs

Tocainide Brand Names Mixture

  • No information avaliable

Tocainide Chemical_Formula


Tocainide RX_link

Tocainide fda sheet

Tocainide msds (material safety sheet)

Tocainide Synthesis Reference

No information avaliable

Tocainide Molecular Weight

192.258 g/mol

Tocainide Melting Point

246-266 oC

Tocainide H2O Solubility

1.07E+004 mg/L

Tocainide State


Tocainide LogP


Tocainide Dosage Forms

400 mg and 600 mg tablets for oral administration

Tocainide Indication

For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening.

Tocainide Pharmacology

Tocainide is a primary amine analog of lidocaine with antiarrhythmic properties useful in the treatment of ventricular arrhythmias. Tocainide, like lidocaine, produces dose dependent decreases in sodium and potassium conductance, thereby decreasing the excitability of myocardial cells. In experimental animal models, the dose-related depression of sodium current is more pronounced in ischemic tissue than in normal tissue. Tocainide is a Class I antiarrhythmic compound with electrophysiologic properties in man similar to those of lidocaine, but dissimilar from quinidine, procainamide, and disopyramide.

Tocainide Absorption

Following oral administration, the bioavailability approaches 100 percent, and is unaffected by food.

Tocainide side effects and Toxicity

The oral LD50 of tocainide was calculated to be about 800 mg/kg in mice, 1000 mg/kg in rats, and 230 mg/kg in guinea pigs; deaths were usually preceded by convulsions.

Tocainide Patient Information

Tocainide Organisms Affected

Humans and other mammals