TBZ 60W en es it fr

TBZ 60W Brand names, TBZ 60W Analogs

TBZ 60W Brand Names Mixture

  • No information avaliable

TBZ 60W Chemical_Formula

C11H16N2O

TBZ 60W RX_link

http://www.rxlist.com/cgi/generic3/tocainide.htm

TBZ 60W fda sheet

TBZ 60W msds (material safety sheet)

TBZ 60W Synthesis Reference

No information avaliable

TBZ 60W Molecular Weight

192.258 g/mol

TBZ 60W Melting Point

246-266 oC

TBZ 60W H2O Solubility

1.07E+004 mg/L

TBZ 60W State

Solid

TBZ 60W LogP

1.308

TBZ 60W Dosage Forms

400 mg and 600 mg tablets for oral administration

TBZ 60W Indication

For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening.

TBZ 60W Pharmacology

Tocainide is a primary amine analog of lidocaine with antiarrhythmic properties useful in the treatment of ventricular arrhythmias. Tocainide, like lidocaine, produces dose dependent decreases in sodium and potassium conductance, thereby decreasing the excitability of myocardial cells. In experimental animal models, the dose-related depression of sodium current is more pronounced in ischemic tissue than in normal tissue. Tocainide is a Class I antiarrhythmic compound with electrophysiologic properties in man similar to those of lidocaine, but dissimilar from quinidine, procainamide, and disopyramide.

TBZ 60W Absorption

Following oral administration, the bioavailability approaches 100 percent, and is unaffected by food.

TBZ 60W side effects and Toxicity

The oral LD50 of tocainide was calculated to be about 800 mg/kg in mice, 1000 mg/kg in rats, and 230 mg/kg in guinea pigs; deaths were usually preceded by convulsions.

TBZ 60W Patient Information

TBZ 60W Organisms Affected

Humans and other mammals