TBZ 60W
Brand names,
TBZ 60W
Analogs
TBZ 60W
Brand Names Mixture
TBZ 60W
Chemical_Formula
C11H16N2O
TBZ 60W
RX_link
http://www.rxlist.com/cgi/generic3/tocainide.htm
TBZ 60W
fda sheet
TBZ 60W
msds (material safety sheet)
TBZ 60W
Synthesis Reference
No information avaliable
TBZ 60W
Molecular Weight
192.258 g/mol
TBZ 60W
Melting Point
246-266 oC
TBZ 60W
H2O Solubility
1.07E+004 mg/L
TBZ 60W
State
Solid
TBZ 60W
LogP
1.308
TBZ 60W
Dosage Forms
400 mg and 600 mg tablets for oral administration
TBZ 60W
Indication
For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening.
TBZ 60W
Pharmacology
Tocainide is a primary amine analog of lidocaine with antiarrhythmic properties useful in the treatment of ventricular arrhythmias. Tocainide, like lidocaine, produces dose dependent decreases in sodium and potassium conductance, thereby decreasing the excitability of myocardial cells. In experimental animal models, the dose-related depression of sodium current is more pronounced in ischemic tissue than in normal tissue. Tocainide is a Class I antiarrhythmic compound with electrophysiologic properties in man similar to those of lidocaine, but dissimilar from quinidine, procainamide, and disopyramide.
TBZ 60W
Absorption
Following oral administration, the bioavailability approaches 100 percent, and is unaffected by food.
TBZ 60W
side effects and Toxicity
The oral LD50 of tocainide was calculated to be about 800 mg/kg in mice, 1000 mg/kg in rats, and 230 mg/kg in guinea pigs; deaths were usually preceded by convulsions.
TBZ 60W
Patient Information
TBZ 60W
Organisms Affected
Humans and other mammals