Thibenzole

Thibenzole Brand names, Thibenzole Analogs

Thibenzole Brand Names Mixture

No information avaliable

Thibenzole Chemical_Formula

C₁₁H₁₆N₂O

Thibenzole RX_link

http://www.rxlist.com/cgi/generic3/tocainide.htm

Thibenzole fda sheet

Thibenzole msds (material safety sheet)

Thibenzole Synthesis Reference

No information avaliable

Thibenzole Molecular Weight

192.258 g/mol

Thibenzole Melting Point

246-266 ^oC

Thibenzole H₂O Solubility

1.07E+004 mg/L

Thibenzole State

Solid

Thibenzole LogP

1.308

Thibenzole Dosage Forms

400 mg and 600 mg tablets for oral administration

Thibenzole Indication

For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening.

Thibenzole Pharmacology

Tocainide is a primary amine analog of lidocaine with antiarrhythmic properties useful in the treatment of ventricular arrhythmias. Tocainide, like lidocaine, produces dose dependent decreases in sodium and potassium conductance, thereby decreasing the excitability of myocardial cells. In experimental animal models, the dose-related depression of sodium current is more pronounced in ischemic tissue than in normal tissue. Tocainide is a Class I antiarrhythmic compound with electrophysiologic properties in man similar to those of lidocaine, but dissimilar from quinidine, procainamide, and disopyramide.

Thibenzole Absorption

Following oral administration, the bioavailability approaches 100 percent, and is unaffected by food.

Thibenzole side effects and Toxicity

The oral LD₅₀ of tocainide was calculated to be about 800 mg/kg in mice, 1000 mg/kg in rats, and 230 mg/kg in guinea pigs; deaths were usually preceded by convulsions.

Thibenzole Patient Information

Thibenzole Organisms Affected

Humans and other mammals