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Thibendole Brand names, Thibendole Analogs

Thibendole Brand Names Mixture

  • No information avaliable

Thibendole Chemical_Formula


Thibendole RX_link

Thibendole fda sheet

Thibendole msds (material safety sheet)

Thibendole Synthesis Reference

No information avaliable

Thibendole Molecular Weight

192.258 g/mol

Thibendole Melting Point

246-266 oC

Thibendole H2O Solubility

1.07E+004 mg/L

Thibendole State


Thibendole LogP


Thibendole Dosage Forms

400 mg and 600 mg tablets for oral administration

Thibendole Indication

For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening.

Thibendole Pharmacology

Tocainide is a primary amine analog of lidocaine with antiarrhythmic properties useful in the treatment of ventricular arrhythmias. Tocainide, like lidocaine, produces dose dependent decreases in sodium and potassium conductance, thereby decreasing the excitability of myocardial cells. In experimental animal models, the dose-related depression of sodium current is more pronounced in ischemic tissue than in normal tissue. Tocainide is a Class I antiarrhythmic compound with electrophysiologic properties in man similar to those of lidocaine, but dissimilar from quinidine, procainamide, and disopyramide.

Thibendole Absorption

Following oral administration, the bioavailability approaches 100 percent, and is unaffected by food.

Thibendole side effects and Toxicity

The oral LD50 of tocainide was calculated to be about 800 mg/kg in mice, 1000 mg/kg in rats, and 230 mg/kg in guinea pigs; deaths were usually preceded by convulsions.

Thibendole Patient Information

Thibendole Organisms Affected

Humans and other mammals