Thibenzol

Thibenzol Brand names, Thibenzol Analogs

Thibenzol Brand Names Mixture

No information avaliable

Thibenzol Chemical_Formula

C₁₁H₁₆N₂O

Thibenzol RX_link

http://www.rxlist.com/cgi/generic3/tocainide.htm

Thibenzol fda sheet

Thibenzol msds (material safety sheet)

Thibenzol Synthesis Reference

No information avaliable

Thibenzol Molecular Weight

192.258 g/mol

Thibenzol Melting Point

246-266 ^oC

Thibenzol H₂O Solubility

1.07E+004 mg/L

Thibenzol State

Solid

Thibenzol LogP

1.308

Thibenzol Dosage Forms

400 mg and 600 mg tablets for oral administration

Thibenzol Indication

For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening.

Thibenzol Pharmacology

Tocainide is a primary amine analog of lidocaine with antiarrhythmic properties useful in the treatment of ventricular arrhythmias. Tocainide, like lidocaine, produces dose dependent decreases in sodium and potassium conductance, thereby decreasing the excitability of myocardial cells. In experimental animal models, the dose-related depression of sodium current is more pronounced in ischemic tissue than in normal tissue. Tocainide is a Class I antiarrhythmic compound with electrophysiologic properties in man similar to those of lidocaine, but dissimilar from quinidine, procainamide, and disopyramide.

Thibenzol Absorption

Following oral administration, the bioavailability approaches 100 percent, and is unaffected by food.

Thibenzol side effects and Toxicity

The oral LD₅₀ of tocainide was calculated to be about 800 mg/kg in mice, 1000 mg/kg in rats, and 230 mg/kg in guinea pigs; deaths were usually preceded by convulsions.

Thibenzol Patient Information

Thibenzol Organisms Affected

Humans and other mammals