Sanaizol 100
Brand names,
Sanaizol 100
Analogs
Sanaizol 100
Brand Names Mixture
Sanaizol 100
Chemical_Formula
C11H16N2O
Sanaizol 100
RX_link
http://www.rxlist.com/cgi/generic3/tocainide.htm
Sanaizol 100
fda sheet
Sanaizol 100
msds (material safety sheet)
Sanaizol 100
Synthesis Reference
No information avaliable
Sanaizol 100
Molecular Weight
192.258 g/mol
Sanaizol 100
Melting Point
246-266 oC
Sanaizol 100
H2O Solubility
1.07E+004 mg/L
Sanaizol 100
State
Solid
Sanaizol 100
LogP
1.308
Sanaizol 100
Dosage Forms
400 mg and 600 mg tablets for oral administration
Sanaizol 100
Indication
For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening.
Sanaizol 100
Pharmacology
Tocainide is a primary amine analog of lidocaine with antiarrhythmic properties useful in the treatment of ventricular arrhythmias. Tocainide, like lidocaine, produces dose dependent decreases in sodium and potassium conductance, thereby decreasing the excitability of myocardial cells. In experimental animal models, the dose-related depression of sodium current is more pronounced in ischemic tissue than in normal tissue. Tocainide is a Class I antiarrhythmic compound with electrophysiologic properties in man similar to those of lidocaine, but dissimilar from quinidine, procainamide, and disopyramide.
Sanaizol 100
Absorption
Following oral administration, the bioavailability approaches 100 percent, and is unaffected by food.
Sanaizol 100
side effects and Toxicity
The oral LD50 of tocainide was calculated to be about 800 mg/kg in mice, 1000 mg/kg in rats, and 230 mg/kg in guinea pigs; deaths were usually preceded by convulsions.
Sanaizol 100
Patient Information
Sanaizol 100
Organisms Affected
Humans and other mammals