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TBZ Brand names, TBZ Analogs

TBZ Brand Names Mixture

  • No information avaliable

TBZ Chemical_Formula


TBZ RX_link


TBZ fda sheet

TBZ msds (material safety sheet)

TBZ Synthesis Reference

No information avaliable

TBZ Molecular Weight

192.258 g/mol

TBZ Melting Point

246-266 oC

TBZ H2O Solubility

1.07E+004 mg/L

TBZ State




TBZ Dosage Forms

400 mg and 600 mg tablets for oral administration

TBZ Indication

For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening.

TBZ Pharmacology

Tocainide is a primary amine analog of lidocaine with antiarrhythmic properties useful in the treatment of ventricular arrhythmias. Tocainide, like lidocaine, produces dose dependent decreases in sodium and potassium conductance, thereby decreasing the excitability of myocardial cells. In experimental animal models, the dose-related depression of sodium current is more pronounced in ischemic tissue than in normal tissue. Tocainide is a Class I antiarrhythmic compound with electrophysiologic properties in man similar to those of lidocaine, but dissimilar from quinidine, procainamide, and disopyramide.

TBZ Absorption

Following oral administration, the bioavailability approaches 100 percent, and is unaffected by food.

TBZ side effects and Toxicity

The oral LD50 of tocainide was calculated to be about 800 mg/kg in mice, 1000 mg/kg in rats, and 230 mg/kg in guinea pigs; deaths were usually preceded by convulsions.

TBZ Patient Information

TBZ Organisms Affected

Humans and other mammals