Metasol TK 10 en es it fr

Metasol TK 10 Brand names, Metasol TK 10 Analogs

Metasol TK 10 Brand Names Mixture

  • No information avaliable

Metasol TK 10 Chemical_Formula


Metasol TK 10 RX_link

Metasol TK 10 fda sheet

Metasol TK 10 msds (material safety sheet)

Metasol TK 10 Synthesis Reference

No information avaliable

Metasol TK 10 Molecular Weight

192.258 g/mol

Metasol TK 10 Melting Point

246-266 oC

Metasol TK 10 H2O Solubility

1.07E+004 mg/L

Metasol TK 10 State


Metasol TK 10 LogP


Metasol TK 10 Dosage Forms

400 mg and 600 mg tablets for oral administration

Metasol TK 10 Indication

For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening.

Metasol TK 10 Pharmacology

Tocainide is a primary amine analog of lidocaine with antiarrhythmic properties useful in the treatment of ventricular arrhythmias. Tocainide, like lidocaine, produces dose dependent decreases in sodium and potassium conductance, thereby decreasing the excitability of myocardial cells. In experimental animal models, the dose-related depression of sodium current is more pronounced in ischemic tissue than in normal tissue. Tocainide is a Class I antiarrhythmic compound with electrophysiologic properties in man similar to those of lidocaine, but dissimilar from quinidine, procainamide, and disopyramide.

Metasol TK 10 Absorption

Following oral administration, the bioavailability approaches 100 percent, and is unaffected by food.

Metasol TK 10 side effects and Toxicity

The oral LD50 of tocainide was calculated to be about 800 mg/kg in mice, 1000 mg/kg in rats, and 230 mg/kg in guinea pigs; deaths were usually preceded by convulsions.

Metasol TK 10 Patient Information

Metasol TK 10 Organisms Affected

Humans and other mammals