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Thiabenzazole Brand names, Thiabenzazole Analogs

Thiabenzazole Brand Names Mixture

  • No information avaliable

Thiabenzazole Chemical_Formula


Thiabenzazole RX_link

Thiabenzazole fda sheet

Thiabenzazole msds (material safety sheet)

Thiabenzazole Synthesis Reference

No information avaliable

Thiabenzazole Molecular Weight

192.258 g/mol

Thiabenzazole Melting Point

246-266 oC

Thiabenzazole H2O Solubility

1.07E+004 mg/L

Thiabenzazole State


Thiabenzazole LogP


Thiabenzazole Dosage Forms

400 mg and 600 mg tablets for oral administration

Thiabenzazole Indication

For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening.

Thiabenzazole Pharmacology

Tocainide is a primary amine analog of lidocaine with antiarrhythmic properties useful in the treatment of ventricular arrhythmias. Tocainide, like lidocaine, produces dose dependent decreases in sodium and potassium conductance, thereby decreasing the excitability of myocardial cells. In experimental animal models, the dose-related depression of sodium current is more pronounced in ischemic tissue than in normal tissue. Tocainide is a Class I antiarrhythmic compound with electrophysiologic properties in man similar to those of lidocaine, but dissimilar from quinidine, procainamide, and disopyramide.

Thiabenzazole Absorption

Following oral administration, the bioavailability approaches 100 percent, and is unaffected by food.

Thiabenzazole side effects and Toxicity

The oral LD50 of tocainide was calculated to be about 800 mg/kg in mice, 1000 mg/kg in rats, and 230 mg/kg in guinea pigs; deaths were usually preceded by convulsions.

Thiabenzazole Patient Information

Thiabenzazole Organisms Affected

Humans and other mammals