Ormogal en es it fr

Ormogal Brand names, Ormogal Analogs

Ormogal Brand Names Mixture

  • No information avaliable

Ormogal Chemical_Formula

C11H16N2O

Ormogal RX_link

http://www.rxlist.com/cgi/generic3/tocainide.htm

Ormogal fda sheet

Ormogal msds (material safety sheet)

Ormogal Synthesis Reference

No information avaliable

Ormogal Molecular Weight

192.258 g/mol

Ormogal Melting Point

246-266 oC

Ormogal H2O Solubility

1.07E+004 mg/L

Ormogal State

Solid

Ormogal LogP

1.308

Ormogal Dosage Forms

400 mg and 600 mg tablets for oral administration

Ormogal Indication

For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening.

Ormogal Pharmacology

Tocainide is a primary amine analog of lidocaine with antiarrhythmic properties useful in the treatment of ventricular arrhythmias. Tocainide, like lidocaine, produces dose dependent decreases in sodium and potassium conductance, thereby decreasing the excitability of myocardial cells. In experimental animal models, the dose-related depression of sodium current is more pronounced in ischemic tissue than in normal tissue. Tocainide is a Class I antiarrhythmic compound with electrophysiologic properties in man similar to those of lidocaine, but dissimilar from quinidine, procainamide, and disopyramide.

Ormogal Absorption

Following oral administration, the bioavailability approaches 100 percent, and is unaffected by food.

Ormogal side effects and Toxicity

The oral LD50 of tocainide was calculated to be about 800 mg/kg in mice, 1000 mg/kg in rats, and 230 mg/kg in guinea pigs; deaths were usually preceded by convulsions.

Ormogal Patient Information

Ormogal Organisms Affected

Humans and other mammals