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Tiabenda Brand names, Tiabenda Analogs

Tiabenda Brand Names Mixture

  • No information avaliable

Tiabenda Chemical_Formula


Tiabenda RX_link


Tiabenda fda sheet

Tiabenda msds (material safety sheet)

Tiabenda Synthesis Reference

No information avaliable

Tiabenda Molecular Weight

192.258 g/mol

Tiabenda Melting Point

246-266 oC

Tiabenda H2O Solubility

1.07E+004 mg/L

Tiabenda State


Tiabenda LogP


Tiabenda Dosage Forms

400 mg and 600 mg tablets for oral administration

Tiabenda Indication

For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening.

Tiabenda Pharmacology

Tocainide is a primary amine analog of lidocaine with antiarrhythmic properties useful in the treatment of ventricular arrhythmias. Tocainide, like lidocaine, produces dose dependent decreases in sodium and potassium conductance, thereby decreasing the excitability of myocardial cells. In experimental animal models, the dose-related depression of sodium current is more pronounced in ischemic tissue than in normal tissue. Tocainide is a Class I antiarrhythmic compound with electrophysiologic properties in man similar to those of lidocaine, but dissimilar from quinidine, procainamide, and disopyramide.

Tiabenda Absorption

Following oral administration, the bioavailability approaches 100 percent, and is unaffected by food.

Tiabenda side effects and Toxicity

The oral LD50 of tocainide was calculated to be about 800 mg/kg in mice, 1000 mg/kg in rats, and 230 mg/kg in guinea pigs; deaths were usually preceded by convulsions.

Tiabenda Patient Information

Tiabenda Organisms Affected

Humans and other mammals