Tecto rph
Brand names,
Tecto rph
Analogs
Tecto rph
Brand Names Mixture
Tecto rph
Chemical_Formula
C11H16N2O
Tecto rph
RX_link
http://www.rxlist.com/cgi/generic3/tocainide.htm
Tecto rph
fda sheet
Tecto rph
msds (material safety sheet)
Tecto rph
Synthesis Reference
No information avaliable
Tecto rph
Molecular Weight
192.258 g/mol
Tecto rph
Melting Point
246-266 oC
Tecto rph
H2O Solubility
1.07E+004 mg/L
Tecto rph
State
Solid
Tecto rph
LogP
1.308
Tecto rph
Dosage Forms
400 mg and 600 mg tablets for oral administration
Tecto rph
Indication
For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening.
Tecto rph
Pharmacology
Tocainide is a primary amine analog of lidocaine with antiarrhythmic properties useful in the treatment of ventricular arrhythmias. Tocainide, like lidocaine, produces dose dependent decreases in sodium and potassium conductance, thereby decreasing the excitability of myocardial cells. In experimental animal models, the dose-related depression of sodium current is more pronounced in ischemic tissue than in normal tissue. Tocainide is a Class I antiarrhythmic compound with electrophysiologic properties in man similar to those of lidocaine, but dissimilar from quinidine, procainamide, and disopyramide.
Tecto rph
Absorption
Following oral administration, the bioavailability approaches 100 percent, and is unaffected by food.
Tecto rph
side effects and Toxicity
The oral LD50 of tocainide was calculated to be about 800 mg/kg in mice, 1000 mg/kg in rats, and 230 mg/kg in guinea pigs; deaths were usually preceded by convulsions.
Tecto rph
Patient Information
Tecto rph
Organisms Affected
Humans and other mammals