Thiabenzole
Thiabenzole Brand names, Thiabenzole Analogs
- Apl-Luster
- Arbotect
- Bioguard
- Bovizole
- Chemviron TK 100
- Cropasal
- Drawipas
- Eprofil
- Equivet TZ
- Equizole
- Hokustar hp
- Hymush
- Lombristop
- Mertec
- Mertect
- Mertect 160
- Mertect 340f
- Mertect lsp
- Metasol TK 100
- Metasol TK 10
- Mintesol
- Mintezol
- Minzolum
- Mycozol
- Nemacin
- Nemapan
- Omnizole
- Ormogal
- Polival
- RPH
- Sanaizol 100
- Sistesan
- Storite
- TBZ 6
- TBZ 60W
- TBDZ
- TBZ
- Tebuzate
- Tecto
- Tecto 10P
- Tecto 40F
- Tecto 60
- Tecto B
- Tecto rph
- Testo
- Thiaben
- Thiabendazol
- Thiabendole
- Thiabenzazole
- Thiabenzole
- Thibendole
- Thibenzol
- Thibenzole
- Thibenzole 200
- Thibenzole att
- Thiprazole
- Tiabenda
- Tiabendazol
- Tiabendazole
- Tibimix 20
- Tobaz
- Top form wormer
- Triasox
- Tubazole
Thiabenzole Brand Names Mixture
- No information avaliable
Thiabenzole Chemical_Formula
C11H16N2O
Thiabenzole RX_link
http://www.rxlist.com/cgi/generic3/tocainide.htm
Thiabenzole fda sheet
Thiabenzole msds (material safety sheet)
Thiabenzole Synthesis Reference
No information avaliable
Thiabenzole Molecular Weight
192.258 g/mol
Thiabenzole Melting Point
246-266 oC
Thiabenzole H2O Solubility
1.07E+004 mg/L
Thiabenzole State
Solid
Thiabenzole LogP
1.308
Thiabenzole Dosage Forms
400 mg and 600 mg tablets for oral administration
Thiabenzole Indication
For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening.
Thiabenzole Pharmacology
Tocainide is a primary amine analog of lidocaine with antiarrhythmic properties useful in the treatment of ventricular arrhythmias. Tocainide, like lidocaine, produces dose dependent decreases in sodium and potassium conductance, thereby decreasing the excitability of myocardial cells. In experimental animal models, the dose-related depression of sodium current is more pronounced in ischemic tissue than in normal tissue. Tocainide is a Class I antiarrhythmic compound with electrophysiologic properties in man similar to those of lidocaine, but dissimilar from quinidine, procainamide, and disopyramide.
Thiabenzole Absorption
Following oral administration, the bioavailability approaches 100 percent, and is unaffected by food.
Thiabenzole side effects and Toxicity
The oral LD50 of tocainide was calculated to be about 800 mg/kg in mice, 1000 mg/kg in rats, and 230 mg/kg in guinea pigs; deaths were usually preceded by convulsions.
Thiabenzole Patient Information
Thiabenzole Organisms Affected
Humans and other mammals
