Thibenzole 200
Brand names,
Thibenzole 200
Analogs
Thibenzole 200
Brand Names Mixture
Thibenzole 200
Chemical_Formula
C11H16N2O
Thibenzole 200
RX_link
http://www.rxlist.com/cgi/generic3/tocainide.htm
Thibenzole 200
fda sheet
Thibenzole 200
msds (material safety sheet)
Thibenzole 200
Synthesis Reference
No information avaliable
Thibenzole 200
Molecular Weight
192.258 g/mol
Thibenzole 200
Melting Point
246-266 oC
Thibenzole 200
H2O Solubility
1.07E+004 mg/L
Thibenzole 200
State
Solid
Thibenzole 200
LogP
1.308
Thibenzole 200
Dosage Forms
400 mg and 600 mg tablets for oral administration
Thibenzole 200
Indication
For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening.
Thibenzole 200
Pharmacology
Tocainide is a primary amine analog of lidocaine with antiarrhythmic properties useful in the treatment of ventricular arrhythmias. Tocainide, like lidocaine, produces dose dependent decreases in sodium and potassium conductance, thereby decreasing the excitability of myocardial cells. In experimental animal models, the dose-related depression of sodium current is more pronounced in ischemic tissue than in normal tissue. Tocainide is a Class I antiarrhythmic compound with electrophysiologic properties in man similar to those of lidocaine, but dissimilar from quinidine, procainamide, and disopyramide.
Thibenzole 200
Absorption
Following oral administration, the bioavailability approaches 100 percent, and is unaffected by food.
Thibenzole 200
side effects and Toxicity
The oral LD50 of tocainide was calculated to be about 800 mg/kg in mice, 1000 mg/kg in rats, and 230 mg/kg in guinea pigs; deaths were usually preceded by convulsions.
Thibenzole 200
Patient Information
Thibenzole 200
Organisms Affected
Humans and other mammals