Thibenzole 200 en es it fr

Thibenzole 200 Brand names, Thibenzole 200 Analogs

Thibenzole 200 Brand Names Mixture

  • No information avaliable

Thibenzole 200 Chemical_Formula


Thibenzole 200 RX_link

Thibenzole 200 fda sheet

Thibenzole 200 msds (material safety sheet)

Thibenzole 200 Synthesis Reference

No information avaliable

Thibenzole 200 Molecular Weight

192.258 g/mol

Thibenzole 200 Melting Point

246-266 oC

Thibenzole 200 H2O Solubility

1.07E+004 mg/L

Thibenzole 200 State


Thibenzole 200 LogP


Thibenzole 200 Dosage Forms

400 mg and 600 mg tablets for oral administration

Thibenzole 200 Indication

For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening.

Thibenzole 200 Pharmacology

Tocainide is a primary amine analog of lidocaine with antiarrhythmic properties useful in the treatment of ventricular arrhythmias. Tocainide, like lidocaine, produces dose dependent decreases in sodium and potassium conductance, thereby decreasing the excitability of myocardial cells. In experimental animal models, the dose-related depression of sodium current is more pronounced in ischemic tissue than in normal tissue. Tocainide is a Class I antiarrhythmic compound with electrophysiologic properties in man similar to those of lidocaine, but dissimilar from quinidine, procainamide, and disopyramide.

Thibenzole 200 Absorption

Following oral administration, the bioavailability approaches 100 percent, and is unaffected by food.

Thibenzole 200 side effects and Toxicity

The oral LD50 of tocainide was calculated to be about 800 mg/kg in mice, 1000 mg/kg in rats, and 230 mg/kg in guinea pigs; deaths were usually preceded by convulsions.

Thibenzole 200 Patient Information

Thibenzole 200 Organisms Affected

Humans and other mammals