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Tiabendazol Brand names, Tiabendazol Analogs

Tiabendazol Brand Names Mixture

  • No information avaliable

Tiabendazol Chemical_Formula

C11H16N2O

Tiabendazol RX_link

http://www.rxlist.com/cgi/generic3/tocainide.htm

Tiabendazol fda sheet

Tiabendazol msds (material safety sheet)

Tiabendazol Synthesis Reference

No information avaliable

Tiabendazol Molecular Weight

192.258 g/mol

Tiabendazol Melting Point

246-266 oC

Tiabendazol H2O Solubility

1.07E+004 mg/L

Tiabendazol State

Solid

Tiabendazol LogP

1.308

Tiabendazol Dosage Forms

400 mg and 600 mg tablets for oral administration

Tiabendazol Indication

For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening.

Tiabendazol Pharmacology

Tocainide is a primary amine analog of lidocaine with antiarrhythmic properties useful in the treatment of ventricular arrhythmias. Tocainide, like lidocaine, produces dose dependent decreases in sodium and potassium conductance, thereby decreasing the excitability of myocardial cells. In experimental animal models, the dose-related depression of sodium current is more pronounced in ischemic tissue than in normal tissue. Tocainide is a Class I antiarrhythmic compound with electrophysiologic properties in man similar to those of lidocaine, but dissimilar from quinidine, procainamide, and disopyramide.

Tiabendazol Absorption

Following oral administration, the bioavailability approaches 100 percent, and is unaffected by food.

Tiabendazol side effects and Toxicity

The oral LD50 of tocainide was calculated to be about 800 mg/kg in mice, 1000 mg/kg in rats, and 230 mg/kg in guinea pigs; deaths were usually preceded by convulsions.

Tiabendazol Patient Information

Tiabendazol Organisms Affected

Humans and other mammals