Thiprazole

Thiprazole Brand names, Thiprazole Analogs

Thiprazole Brand Names Mixture

No information avaliable

Thiprazole Chemical_Formula

C₁₁H₁₆N₂O

Thiprazole RX_link

http://www.rxlist.com/cgi/generic3/tocainide.htm

Thiprazole fda sheet

Thiprazole msds (material safety sheet)

Thiprazole Synthesis Reference

No information avaliable

Thiprazole Molecular Weight

192.258 g/mol

Thiprazole Melting Point

246-266 ^oC

Thiprazole H₂O Solubility

1.07E+004 mg/L

Thiprazole State

Solid

Thiprazole LogP

1.308

Thiprazole Dosage Forms

400 mg and 600 mg tablets for oral administration

Thiprazole Indication

For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening.

Thiprazole Pharmacology

Tocainide is a primary amine analog of lidocaine with antiarrhythmic properties useful in the treatment of ventricular arrhythmias. Tocainide, like lidocaine, produces dose dependent decreases in sodium and potassium conductance, thereby decreasing the excitability of myocardial cells. In experimental animal models, the dose-related depression of sodium current is more pronounced in ischemic tissue than in normal tissue. Tocainide is a Class I antiarrhythmic compound with electrophysiologic properties in man similar to those of lidocaine, but dissimilar from quinidine, procainamide, and disopyramide.

Thiprazole Absorption

Following oral administration, the bioavailability approaches 100 percent, and is unaffected by food.

Thiprazole side effects and Toxicity

The oral LD₅₀ of tocainide was calculated to be about 800 mg/kg in mice, 1000 mg/kg in rats, and 230 mg/kg in guinea pigs; deaths were usually preceded by convulsions.

Thiprazole Patient Information

Thiprazole Organisms Affected

Humans and other mammals