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Omnizole Brand names, Omnizole Analogs

Omnizole Brand Names Mixture

  • No information avaliable

Omnizole Chemical_Formula

C11H16N2O

Omnizole RX_link

http://www.rxlist.com/cgi/generic3/tocainide.htm

Omnizole fda sheet

Omnizole msds (material safety sheet)

Omnizole Synthesis Reference

No information avaliable

Omnizole Molecular Weight

192.258 g/mol

Omnizole Melting Point

246-266 oC

Omnizole H2O Solubility

1.07E+004 mg/L

Omnizole State

Solid

Omnizole LogP

1.308

Omnizole Dosage Forms

400 mg and 600 mg tablets for oral administration

Omnizole Indication

For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening.

Omnizole Pharmacology

Tocainide is a primary amine analog of lidocaine with antiarrhythmic properties useful in the treatment of ventricular arrhythmias. Tocainide, like lidocaine, produces dose dependent decreases in sodium and potassium conductance, thereby decreasing the excitability of myocardial cells. In experimental animal models, the dose-related depression of sodium current is more pronounced in ischemic tissue than in normal tissue. Tocainide is a Class I antiarrhythmic compound with electrophysiologic properties in man similar to those of lidocaine, but dissimilar from quinidine, procainamide, and disopyramide.

Omnizole Absorption

Following oral administration, the bioavailability approaches 100 percent, and is unaffected by food.

Omnizole side effects and Toxicity

The oral LD50 of tocainide was calculated to be about 800 mg/kg in mice, 1000 mg/kg in rats, and 230 mg/kg in guinea pigs; deaths were usually preceded by convulsions.

Omnizole Patient Information

Omnizole Organisms Affected

Humans and other mammals