Tibimix 20

Tibimix 20 Brand names, Tibimix 20 Analogs

Tibimix 20 Brand Names Mixture

No information avaliable

Tibimix 20 Chemical_Formula

C₁₁H₁₆N₂O

Tibimix 20 RX_link

http://www.rxlist.com/cgi/generic3/tocainide.htm

Tibimix 20 fda sheet

Tibimix 20 msds (material safety sheet)

Tibimix 20 Synthesis Reference

No information avaliable

Tibimix 20 Molecular Weight

192.258 g/mol

Tibimix 20 Melting Point

246-266 ^oC

Tibimix 20 H₂O Solubility

1.07E+004 mg/L

Tibimix 20 State

Solid

Tibimix 20 LogP

1.308

Tibimix 20 Dosage Forms

400 mg and 600 mg tablets for oral administration

Tibimix 20 Indication

For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening.

Tibimix 20 Pharmacology

Tocainide is a primary amine analog of lidocaine with antiarrhythmic properties useful in the treatment of ventricular arrhythmias. Tocainide, like lidocaine, produces dose dependent decreases in sodium and potassium conductance, thereby decreasing the excitability of myocardial cells. In experimental animal models, the dose-related depression of sodium current is more pronounced in ischemic tissue than in normal tissue. Tocainide is a Class I antiarrhythmic compound with electrophysiologic properties in man similar to those of lidocaine, but dissimilar from quinidine, procainamide, and disopyramide.

Tibimix 20 Absorption

Following oral administration, the bioavailability approaches 100 percent, and is unaffected by food.

Tibimix 20 side effects and Toxicity

The oral LD₅₀ of tocainide was calculated to be about 800 mg/kg in mice, 1000 mg/kg in rats, and 230 mg/kg in guinea pigs; deaths were usually preceded by convulsions.

Tibimix 20 Patient Information

Tibimix 20 Organisms Affected

Humans and other mammals