Polival

Polival Brand names, Polival Analogs

Polival Brand Names Mixture

No information avaliable

Polival Chemical_Formula

C₁₁H₁₆N₂O

Polival RX_link

http://www.rxlist.com/cgi/generic3/tocainide.htm

Polival fda sheet

Polival msds (material safety sheet)

Polival Synthesis Reference

No information avaliable

Polival Molecular Weight

192.258 g/mol

Polival Melting Point

246-266 ^oC

Polival H₂O Solubility

1.07E+004 mg/L

Polival State

Solid

Polival LogP

1.308

Polival Dosage Forms

400 mg and 600 mg tablets for oral administration

Polival Indication

For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening.

Polival Pharmacology

Tocainide is a primary amine analog of lidocaine with antiarrhythmic properties useful in the treatment of ventricular arrhythmias. Tocainide, like lidocaine, produces dose dependent decreases in sodium and potassium conductance, thereby decreasing the excitability of myocardial cells. In experimental animal models, the dose-related depression of sodium current is more pronounced in ischemic tissue than in normal tissue. Tocainide is a Class I antiarrhythmic compound with electrophysiologic properties in man similar to those of lidocaine, but dissimilar from quinidine, procainamide, and disopyramide.

Polival Absorption

Following oral administration, the bioavailability approaches 100 percent, and is unaffected by food.

Polival side effects and Toxicity

The oral LD₅₀ of tocainide was calculated to be about 800 mg/kg in mice, 1000 mg/kg in rats, and 230 mg/kg in guinea pigs; deaths were usually preceded by convulsions.

Polival Patient Information

Polival Organisms Affected

Humans and other mammals