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Thiaben Brand names, Thiaben Analogs

Thiaben Brand Names Mixture

  • No information avaliable

Thiaben Chemical_Formula


Thiaben RX_link

Thiaben fda sheet

Thiaben msds (material safety sheet)

Thiaben Synthesis Reference

No information avaliable

Thiaben Molecular Weight

192.258 g/mol

Thiaben Melting Point

246-266 oC

Thiaben H2O Solubility

1.07E+004 mg/L

Thiaben State


Thiaben LogP


Thiaben Dosage Forms

400 mg and 600 mg tablets for oral administration

Thiaben Indication

For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening.

Thiaben Pharmacology

Tocainide is a primary amine analog of lidocaine with antiarrhythmic properties useful in the treatment of ventricular arrhythmias. Tocainide, like lidocaine, produces dose dependent decreases in sodium and potassium conductance, thereby decreasing the excitability of myocardial cells. In experimental animal models, the dose-related depression of sodium current is more pronounced in ischemic tissue than in normal tissue. Tocainide is a Class I antiarrhythmic compound with electrophysiologic properties in man similar to those of lidocaine, but dissimilar from quinidine, procainamide, and disopyramide.

Thiaben Absorption

Following oral administration, the bioavailability approaches 100 percent, and is unaffected by food.

Thiaben side effects and Toxicity

The oral LD50 of tocainide was calculated to be about 800 mg/kg in mice, 1000 mg/kg in rats, and 230 mg/kg in guinea pigs; deaths were usually preceded by convulsions.

Thiaben Patient Information

Thiaben Organisms Affected

Humans and other mammals