Thibenzole att

Thibenzole att Brand names, Thibenzole att Analogs

Thibenzole att Brand Names Mixture

No information avaliable

Thibenzole att Chemical_Formula

C₁₁H₁₆N₂O

Thibenzole att RX_link

http://www.rxlist.com/cgi/generic3/tocainide.htm

Thibenzole att fda sheet

Thibenzole att msds (material safety sheet)

Thibenzole att Synthesis Reference

No information avaliable

Thibenzole att Molecular Weight

192.258 g/mol

Thibenzole att Melting Point

246-266 ^oC

Thibenzole att H₂O Solubility

1.07E+004 mg/L

Thibenzole att State

Solid

Thibenzole att LogP

1.308

Thibenzole att Dosage Forms

400 mg and 600 mg tablets for oral administration

Thibenzole att Indication

For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening.

Thibenzole att Pharmacology

Tocainide is a primary amine analog of lidocaine with antiarrhythmic properties useful in the treatment of ventricular arrhythmias. Tocainide, like lidocaine, produces dose dependent decreases in sodium and potassium conductance, thereby decreasing the excitability of myocardial cells. In experimental animal models, the dose-related depression of sodium current is more pronounced in ischemic tissue than in normal tissue. Tocainide is a Class I antiarrhythmic compound with electrophysiologic properties in man similar to those of lidocaine, but dissimilar from quinidine, procainamide, and disopyramide.

Thibenzole att Absorption

Following oral administration, the bioavailability approaches 100 percent, and is unaffected by food.

Thibenzole att side effects and Toxicity

The oral LD₅₀ of tocainide was calculated to be about 800 mg/kg in mice, 1000 mg/kg in rats, and 230 mg/kg in guinea pigs; deaths were usually preceded by convulsions.

Thibenzole att Patient Information

Thibenzole att Organisms Affected

Humans and other mammals