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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C11H16N2O
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RX_link
http://www.rxlist.com/cgi/generic3/tocainide.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
192.258 g/mol
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Melting Point
246-266 oC
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H2O Solubility
1.07E+004 mg/L
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State
Solid
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LogP
1.308
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Dosage Forms
400 mg and 600 mg tablets for oral administration
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Indication
For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening.
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Pharmacology
Tocainide is a primary amine analog of lidocaine with antiarrhythmic properties useful in the treatment of ventricular arrhythmias. Tocainide, like lidocaine, produces dose dependent decreases in sodium and potassium conductance, thereby decreasing the excitability of myocardial cells. In experimental animal models, the dose-related depression of sodium current is more pronounced in ischemic tissue than in normal tissue. Tocainide is a Class I antiarrhythmic compound with electrophysiologic properties in man similar to those of lidocaine, but dissimilar from quinidine, procainamide, and disopyramide.
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Absorption
Following oral administration, the bioavailability approaches 100 percent, and is unaffected by food.
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side effects and Toxicity
The oral LD50 of tocainide was calculated to be about 800 mg/kg in mice, 1000 mg/kg in rats, and 230 mg/kg in guinea pigs; deaths were usually preceded by convulsions.
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Patient Information
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Organisms Affected
Humans and other mammals