Estrone
Brand names,
Estrone
Analogs
Estrone
Brand Names Mixture
- Cimicifuga Plex (Caulophyllum Thalictroides + Cimicifuga Racemosa + Copper + Cotton Plant + Estrone + Histamine Dihydrochloride + Hypothalamus + Magnesium Phosphate Dibasic + Pituitary Whole + Platinum + Sepia Officinalis L + Thyroid)
- Holis 98 (Dioscorea Vilosa + Estrone + Salvia + Saw Palmetto)
Estrone
Chemical_Formula
C18H22O2
Estrone
RX_link
No information avaliable
Estrone
fda sheet
Estrone
msds (material safety sheet)
Estrone
Synthesis Reference
G. Anner, K. Miescher, and Helv. Chem. Acta. 31, 2173(1948)
Estrone
Molecular Weight
270.366 g/mol
Estrone
Melting Point
254.5-256 oC
Estrone
H2O Solubility
3 g/100mL
Estrone
State
Solid
Estrone
LogP
4.067
Estrone
Dosage Forms
Vaginal cream; Vaginal suppository; Patch; Skin gel; Tablet; IM injectable suspension
Estrone
Indication
For management of Menopausal and postmenopausal disorders
Estrone
Pharmacology
Estrone, a synthetically prepared or naturally occurring steroidal estrogen obtained from pregnant equine urine, is the primary circulating estrogen after menopause. Estrone is naturally derived from the peripheral conversion of androstenedione by an aromatase enzyme found in adipose tissues and is converted to estradiol in peripheral tissues. Estropipate is piperazine-stabilized estrone sulfate. Estrone, and estropipate are used to treat abnormalities related to gonadotropin hormone dysfunction, vasomotor symptoms, atrophic vaginitis, and vulvar atrophy associated with menopause, and for the prevention of osteoporosis due to estrogen deficiency.
Estrone
Absorption
43%
Estrone
side effects and Toxicity
Symptoms of overdose include nausea and vomiting. Withdrawal bleeding may occur in females.
Estrone
Patient Information
Estrone
Organisms Affected
Humans and other mammals