Follestrol
Brand names,
Follestrol
Analogs
Follestrol
Brand Names Mixture
- Cimicifuga Plex (Caulophyllum Thalictroides + Cimicifuga Racemosa + Copper + Cotton Plant + Estrone + Histamine Dihydrochloride + Hypothalamus + Magnesium Phosphate Dibasic + Pituitary Whole + Platinum + Sepia Officinalis L + Thyroid)
- Holis 98 (Dioscorea Vilosa + Estrone + Salvia + Saw Palmetto)
Follestrol
Chemical_Formula
C18H22O2
Follestrol
RX_link
No information avaliable
Follestrol
fda sheet
Follestrol
msds (material safety sheet)
Follestrol
Synthesis Reference
G. Anner, K. Miescher, and Helv. Chem. Acta. 31, 2173(1948)
Follestrol
Molecular Weight
270.366 g/mol
Follestrol
Melting Point
254.5-256 oC
Follestrol
H2O Solubility
3 g/100mL
Follestrol
State
Solid
Follestrol
LogP
4.067
Follestrol
Dosage Forms
Vaginal cream; Vaginal suppository; Patch; Skin gel; Tablet; IM injectable suspension
Follestrol
Indication
For management of Menopausal and postmenopausal disorders
Follestrol
Pharmacology
Estrone, a synthetically prepared or naturally occurring steroidal estrogen obtained from pregnant equine urine, is the primary circulating estrogen after menopause. Estrone is naturally derived from the peripheral conversion of androstenedione by an aromatase enzyme found in adipose tissues and is converted to estradiol in peripheral tissues. Estropipate is piperazine-stabilized estrone sulfate. Estrone, and estropipate are used to treat abnormalities related to gonadotropin hormone dysfunction, vasomotor symptoms, atrophic vaginitis, and vulvar atrophy associated with menopause, and for the prevention of osteoporosis due to estrogen deficiency.
Follestrol
Absorption
43%
Follestrol
side effects and Toxicity
Symptoms of overdose include nausea and vomiting. Withdrawal bleeding may occur in females.
Follestrol
Patient Information
Follestrol
Organisms Affected
Humans and other mammals