Tokokin
Brand names,
Tokokin
Analogs
Tokokin
Brand Names Mixture
- Cimicifuga Plex (Caulophyllum Thalictroides + Cimicifuga Racemosa + Copper + Cotton Plant + Estrone + Histamine Dihydrochloride + Hypothalamus + Magnesium Phosphate Dibasic + Pituitary Whole + Platinum + Sepia Officinalis L + Thyroid)
- Holis 98 (Dioscorea Vilosa + Estrone + Salvia + Saw Palmetto)
Tokokin
Chemical_Formula
C18H22O2
Tokokin
RX_link
No information avaliable
Tokokin
fda sheet
Tokokin
msds (material safety sheet)
Tokokin
Synthesis Reference
G. Anner, K. Miescher, and Helv. Chem. Acta. 31, 2173(1948)
Tokokin
Molecular Weight
270.366 g/mol
Tokokin
Melting Point
254.5-256 oC
Tokokin
H2O Solubility
3 g/100mL
Tokokin
State
Solid
Tokokin
LogP
4.067
Tokokin
Dosage Forms
Vaginal cream; Vaginal suppository; Patch; Skin gel; Tablet; IM injectable suspension
Tokokin
Indication
For management of Menopausal and postmenopausal disorders
Tokokin
Pharmacology
Estrone, a synthetically prepared or naturally occurring steroidal estrogen obtained from pregnant equine urine, is the primary circulating estrogen after menopause. Estrone is naturally derived from the peripheral conversion of androstenedione by an aromatase enzyme found in adipose tissues and is converted to estradiol in peripheral tissues. Estropipate is piperazine-stabilized estrone sulfate. Estrone, and estropipate are used to treat abnormalities related to gonadotropin hormone dysfunction, vasomotor symptoms, atrophic vaginitis, and vulvar atrophy associated with menopause, and for the prevention of osteoporosis due to estrogen deficiency.
Tokokin
Absorption
43%
Tokokin
side effects and Toxicity
Symptoms of overdose include nausea and vomiting. Withdrawal bleeding may occur in females.
Tokokin
Patient Information
Tokokin
Organisms Affected
Humans and other mammals