Follestrine
Brand names,
Follestrine
Analogs
Follestrine
Brand Names Mixture
- Cimicifuga Plex (Caulophyllum Thalictroides + Cimicifuga Racemosa + Copper + Cotton Plant + Estrone + Histamine Dihydrochloride + Hypothalamus + Magnesium Phosphate Dibasic + Pituitary Whole + Platinum + Sepia Officinalis L + Thyroid)
- Holis 98 (Dioscorea Vilosa + Estrone + Salvia + Saw Palmetto)
Follestrine
Chemical_Formula
C18H22O2
Follestrine
RX_link
No information avaliable
Follestrine
fda sheet
Follestrine
msds (material safety sheet)
Follestrine
Synthesis Reference
G. Anner, K. Miescher, and Helv. Chem. Acta. 31, 2173(1948)
Follestrine
Molecular Weight
270.366 g/mol
Follestrine
Melting Point
254.5-256 oC
Follestrine
H2O Solubility
3 g/100mL
Follestrine
State
Solid
Follestrine
LogP
4.067
Follestrine
Dosage Forms
Vaginal cream; Vaginal suppository; Patch; Skin gel; Tablet; IM injectable suspension
Follestrine
Indication
For management of Menopausal and postmenopausal disorders
Follestrine
Pharmacology
Estrone, a synthetically prepared or naturally occurring steroidal estrogen obtained from pregnant equine urine, is the primary circulating estrogen after menopause. Estrone is naturally derived from the peripheral conversion of androstenedione by an aromatase enzyme found in adipose tissues and is converted to estradiol in peripheral tissues. Estropipate is piperazine-stabilized estrone sulfate. Estrone, and estropipate are used to treat abnormalities related to gonadotropin hormone dysfunction, vasomotor symptoms, atrophic vaginitis, and vulvar atrophy associated with menopause, and for the prevention of osteoporosis due to estrogen deficiency.
Follestrine
Absorption
43%
Follestrine
side effects and Toxicity
Symptoms of overdose include nausea and vomiting. Withdrawal bleeding may occur in females.
Follestrine
Patient Information
Follestrine
Organisms Affected
Humans and other mammals