Estrugenone
Brand names,
Estrugenone
Analogs
Estrugenone
Brand Names Mixture
- Cimicifuga Plex (Caulophyllum Thalictroides + Cimicifuga Racemosa + Copper + Cotton Plant + Estrone + Histamine Dihydrochloride + Hypothalamus + Magnesium Phosphate Dibasic + Pituitary Whole + Platinum + Sepia Officinalis L + Thyroid)
- Holis 98 (Dioscorea Vilosa + Estrone + Salvia + Saw Palmetto)
Estrugenone
Chemical_Formula
C18H22O2
Estrugenone
RX_link
No information avaliable
Estrugenone
fda sheet
Estrugenone
msds (material safety sheet)
Estrugenone
Synthesis Reference
G. Anner, K. Miescher, and Helv. Chem. Acta. 31, 2173(1948)
Estrugenone
Molecular Weight
270.366 g/mol
Estrugenone
Melting Point
254.5-256 oC
Estrugenone
H2O Solubility
3 g/100mL
Estrugenone
State
Solid
Estrugenone
LogP
4.067
Estrugenone
Dosage Forms
Vaginal cream; Vaginal suppository; Patch; Skin gel; Tablet; IM injectable suspension
Estrugenone
Indication
For management of Menopausal and postmenopausal disorders
Estrugenone
Pharmacology
Estrone, a synthetically prepared or naturally occurring steroidal estrogen obtained from pregnant equine urine, is the primary circulating estrogen after menopause. Estrone is naturally derived from the peripheral conversion of androstenedione by an aromatase enzyme found in adipose tissues and is converted to estradiol in peripheral tissues. Estropipate is piperazine-stabilized estrone sulfate. Estrone, and estropipate are used to treat abnormalities related to gonadotropin hormone dysfunction, vasomotor symptoms, atrophic vaginitis, and vulvar atrophy associated with menopause, and for the prevention of osteoporosis due to estrogen deficiency.
Estrugenone
Absorption
43%
Estrugenone
side effects and Toxicity
Symptoms of overdose include nausea and vomiting. Withdrawal bleeding may occur in females.
Estrugenone
Patient Information
Estrugenone
Organisms Affected
Humans and other mammals