Estrogenic Substance
Brand names,
Estrogenic Substance
Analogs
Estrogenic Substance
Brand Names Mixture
- Cimicifuga Plex (Caulophyllum Thalictroides + Cimicifuga Racemosa + Copper + Cotton Plant + Estrone + Histamine Dihydrochloride + Hypothalamus + Magnesium Phosphate Dibasic + Pituitary Whole + Platinum + Sepia Officinalis L + Thyroid)
- Holis 98 (Dioscorea Vilosa + Estrone + Salvia + Saw Palmetto)
Estrogenic Substance
Chemical_Formula
C18H22O2
Estrogenic Substance
RX_link
No information avaliable
Estrogenic Substance
fda sheet
Estrogenic Substance
msds (material safety sheet)
Estrogenic Substance
Synthesis Reference
G. Anner, K. Miescher, and Helv. Chem. Acta. 31, 2173(1948)
Estrogenic Substance
Molecular Weight
270.366 g/mol
Estrogenic Substance
Melting Point
254.5-256 oC
Estrogenic Substance
H2O Solubility
3 g/100mL
Estrogenic Substance
State
Solid
Estrogenic Substance
LogP
4.067
Estrogenic Substance
Dosage Forms
Vaginal cream; Vaginal suppository; Patch; Skin gel; Tablet; IM injectable suspension
Estrogenic Substance
Indication
For management of Menopausal and postmenopausal disorders
Estrogenic Substance
Pharmacology
Estrone, a synthetically prepared or naturally occurring steroidal estrogen obtained from pregnant equine urine, is the primary circulating estrogen after menopause. Estrone is naturally derived from the peripheral conversion of androstenedione by an aromatase enzyme found in adipose tissues and is converted to estradiol in peripheral tissues. Estropipate is piperazine-stabilized estrone sulfate. Estrone, and estropipate are used to treat abnormalities related to gonadotropin hormone dysfunction, vasomotor symptoms, atrophic vaginitis, and vulvar atrophy associated with menopause, and for the prevention of osteoporosis due to estrogen deficiency.
Estrogenic Substance
Absorption
43%
Estrogenic Substance
side effects and Toxicity
Symptoms of overdose include nausea and vomiting. Withdrawal bleeding may occur in females.
Estrogenic Substance
Patient Information
Estrogenic Substance
Organisms Affected
Humans and other mammals