Oestrone [Steroidal Oestrogens]
Brand names,
Oestrone [Steroidal Oestrogens]
Analogs
Oestrone [Steroidal Oestrogens]
Brand Names Mixture
- Cimicifuga Plex (Caulophyllum Thalictroides + Cimicifuga Racemosa + Copper + Cotton Plant + Estrone + Histamine Dihydrochloride + Hypothalamus + Magnesium Phosphate Dibasic + Pituitary Whole + Platinum + Sepia Officinalis L + Thyroid)
- Holis 98 (Dioscorea Vilosa + Estrone + Salvia + Saw Palmetto)
Oestrone [Steroidal Oestrogens]
Chemical_Formula
C18H22O2
Oestrone [Steroidal Oestrogens]
RX_link
No information avaliable
Oestrone [Steroidal Oestrogens]
fda sheet
Oestrone [Steroidal Oestrogens]
msds (material safety sheet)
Oestrone [Steroidal Oestrogens]
Synthesis Reference
G. Anner, K. Miescher, and Helv. Chem. Acta. 31, 2173(1948)
Oestrone [Steroidal Oestrogens]
Molecular Weight
270.366 g/mol
Oestrone [Steroidal Oestrogens]
Melting Point
254.5-256 oC
Oestrone [Steroidal Oestrogens]
H2O Solubility
3 g/100mL
Oestrone [Steroidal Oestrogens]
State
Solid
Oestrone [Steroidal Oestrogens]
LogP
4.067
Oestrone [Steroidal Oestrogens]
Dosage Forms
Vaginal cream; Vaginal suppository; Patch; Skin gel; Tablet; IM injectable suspension
Oestrone [Steroidal Oestrogens]
Indication
For management of Menopausal and postmenopausal disorders
Oestrone [Steroidal Oestrogens]
Pharmacology
Estrone, a synthetically prepared or naturally occurring steroidal estrogen obtained from pregnant equine urine, is the primary circulating estrogen after menopause. Estrone is naturally derived from the peripheral conversion of androstenedione by an aromatase enzyme found in adipose tissues and is converted to estradiol in peripheral tissues. Estropipate is piperazine-stabilized estrone sulfate. Estrone, and estropipate are used to treat abnormalities related to gonadotropin hormone dysfunction, vasomotor symptoms, atrophic vaginitis, and vulvar atrophy associated with menopause, and for the prevention of osteoporosis due to estrogen deficiency.
Oestrone [Steroidal Oestrogens]
Absorption
43%
Oestrone [Steroidal Oestrogens]
side effects and Toxicity
Symptoms of overdose include nausea and vomiting. Withdrawal bleeding may occur in females.
Oestrone [Steroidal Oestrogens]
Patient Information
Oestrone [Steroidal Oestrogens]
Organisms Affected
Humans and other mammals