Oestrone

• Estrogens
• ATC:G03CA57

• Conestoral
• Estrone-sulfate
• Estrogens
• Estrone Estrone Hydrogen Sulfate
• Estrone Hydrogen Sulfate
• Estrone Sodium Sulfate
• Estrone Sulfate
• Estrone Sulfate Sodium
• Estrone Sulphate
• Evex
• Hyhorin
• Morestin
• Oestrone Sulphate
• Par Estro
• Premarin
• Prempro/Premphase
• Sodium Estrone Sulfate

• Prempro (conjugated estrogens + medroxyprogesteron)

C₁₈H₂₁NaO₅S

http://www.rxlist.com/cgi/generic/conest.htm

Oestrone FDA

Oestrone MSDS

Bates, Cohen, U.S. Pat. 2,565,115 (1951)

372.412 g/mol

173 ^oC

0.0036 mg/ml

solid

No information avaliable

Tablet; Injection; Vaginal cream; Topical gel

For the treatment of moderate to severe vasomotor symptoms associated with the menopause, atrophic vaginitis, osteoporosis, hypoestrogenism due to hypogonadism, castration, primary ovarian failure, breast cancer (for palliation only), and Advanced androgen-dependent carcinoma of the prostate (for palliation only)

Conjugated estrogens, a mixture of the water soluble salts of sulfate esters from estrone, equilin, 17 α-dihydroequilin, and other related steroids, may be derived from pregnant equine urine or yam and soy plants. Estrogens are important in the development and maintenance of the female reproductive system and secondary sex characteristics. They promote growth and development of the vagina, uterus, and fallopian tubes, and enlargement of the breasts. Indirectly, they contribute to the shaping of the skeleton, maintenance of tone and elasticity of urogenital structures, changes in the epiphyses of the long bones that allow for the pubertal growth spurt and its termination, growth of axillary and pubic hair, and pigmentation of the nipples and genitals. Decline of estrogenic activity at the end of the menstrual cycle can bring on menstruation, although the cessation of progesterone secretion is the most important factor in the mature ovulatory cycle. However, in the preovulatory or nonovulatory cycle, estrogen is the primary determinant in the onset of menstruation. Estrogens also affect the release of pituitary gonadotropins. The pharmacologic effects of conjugated estrogens are similar to those of endogenous estrogens.

Well absorbed

Nausea and vomiting

Humans and other mammals