Zorane
Category
Zorane Brand names, Zorane Analogs
Zorane Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Zorane Chemical_Formula
C19H20N2O2
Zorane RX_link
No information avaliable
Zorane fda sheet
Zorane msds (material safety sheet)
Zorane Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Zorane Molecular Weight
308.374 g/mol
Zorane Melting Point
105 oC
Zorane H2O Solubility
47.5 mg/L
Zorane State
Solid
Zorane LogP
4.214
Zorane Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Zorane Indication
For the treatment of backache and ankylosing spondylitis
Zorane Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Zorane Absorption
No information avaliable
Zorane Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Zorane Patient Information
No information avaliable
Zorane Organisms Affected
Humans and other mammals
