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Butazolidine
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Butazolidine Brand names, Butazolidine Analogs

Butazolidine Brand Names Mixture

  • Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
  • Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
  • Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)

Butazolidine Chemical_Formula

C19H20N2O2

Butazolidine RX_link

No information avaliable

Butazolidine fda sheet

Butazolidine msds (material safety sheet)

Butazolidine MSDS

Butazolidine Synthesis Reference

Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)

Butazolidine Molecular Weight

308.374 g/mol

Butazolidine Melting Point

105 oC

Butazolidine H2O Solubility

47.5 mg/L

Butazolidine State

Solid

Butazolidine LogP

4.214

Butazolidine Dosage Forms

Bolus; Liquid; Paste; Powder; Solution; Tablet

Butazolidine Indication

For the treatment of backache and ankylosing spondylitis

Butazolidine Pharmacology

Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation

Butazolidine Absorption

No information avaliable

Butazolidine side effects and Toxicity

Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)

Butazolidine Patient Information

No information avaliable

Butazolidine Organisms Affected

Humans and other mammals