Fenilbutazona
Category
Fenilbutazona Brand names, Fenilbutazona Analogs
Fenilbutazona Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Fenilbutazona Chemical_Formula
C19H20N2O2
Fenilbutazona RX_link
No information avaliable
Fenilbutazona fda sheet
Fenilbutazona msds (material safety sheet)
Fenilbutazona Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Fenilbutazona Molecular Weight
308.374 g/mol
Fenilbutazona Melting Point
105 oC
Fenilbutazona H2O Solubility
47.5 mg/L
Fenilbutazona State
Solid
Fenilbutazona LogP
4.214
Fenilbutazona Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Fenilbutazona Indication
For the treatment of backache and ankylosing spondylitis
Fenilbutazona Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Fenilbutazona Absorption
No information avaliable
Fenilbutazona side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Fenilbutazona Patient Information
No information avaliable
Fenilbutazona Organisms Affected
Humans and other mammals
