VAC-10 en es it fr

VAC-10 Brand names, VAC-10 Analogs

VAC-10 Brand Names Mixture

  • Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
  • Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
  • Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)

VAC-10 Chemical_Formula

C19H20N2O2

VAC-10 RX_link

No information avaliable

VAC-10 fda sheet

VAC-10 msds (material safety sheet)

VAC-10 MSDS

VAC-10 Synthesis Reference

Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)

VAC-10 Molecular Weight

308.374 g/mol

VAC-10 Melting Point

105 oC

VAC-10 H2O Solubility

47.5 mg/L

VAC-10 State

Solid

VAC-10 LogP

4.214

VAC-10 Dosage Forms

Bolus; Liquid; Paste; Powder; Solution; Tablet

VAC-10 Indication

For the treatment of backache and ankylosing spondylitis

VAC-10 Pharmacology

Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation

VAC-10 Absorption

No information avaliable

VAC-10 side effects and Toxicity

Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)

VAC-10 Patient Information

No information avaliable

VAC-10 Organisms Affected

Humans and other mammals