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PBZ Brand names, PBZ Analogs

PBZ Brand Names Mixture

  • Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
  • Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
  • Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)

PBZ Chemical_Formula

C19H20N2O2

PBZ RX_link

No information avaliable

PBZ fda sheet

PBZ msds (material safety sheet)

PBZ MSDS

PBZ Synthesis Reference

Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)

PBZ Molecular Weight

308.374 g/mol

PBZ Melting Point

105 oC

PBZ H2O Solubility

47.5 mg/L

PBZ State

Solid

PBZ LogP

4.214

PBZ Dosage Forms

Bolus; Liquid; Paste; Powder; Solution; Tablet

PBZ Indication

For the treatment of backache and ankylosing spondylitis

PBZ Pharmacology

Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation

PBZ Absorption

No information avaliable

PBZ side effects and Toxicity

Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)

PBZ Patient Information

No information avaliable

PBZ Organisms Affected

Humans and other mammals