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Rubatone Brand names, Rubatone Analogs

Rubatone Brand Names Mixture

  • Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
  • Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
  • Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)

Rubatone Chemical_Formula

C19H20N2O2

Rubatone RX_link

No information avaliable

Rubatone fda sheet

Rubatone msds (material safety sheet)

Rubatone MSDS

Rubatone Synthesis Reference

Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)

Rubatone Molecular Weight

308.374 g/mol

Rubatone Melting Point

105 oC

Rubatone H2O Solubility

47.5 mg/L

Rubatone State

Solid

Rubatone LogP

4.214

Rubatone Dosage Forms

Bolus; Liquid; Paste; Powder; Solution; Tablet

Rubatone Indication

For the treatment of backache and ankylosing spondylitis

Rubatone Pharmacology

Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation

Rubatone Absorption

No information avaliable

Rubatone side effects and Toxicity

Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)

Rubatone Patient Information

No information avaliable

Rubatone Organisms Affected

Humans and other mammals