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Butone Brand names, Butone Analogs

Butone Brand Names Mixture

  • Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
  • Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
  • Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)

Butone Chemical_Formula

C19H20N2O2

Butone RX_link

No information avaliable

Butone fda sheet

Butone msds (material safety sheet)

Butone MSDS

Butone Synthesis Reference

Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)

Butone Molecular Weight

308.374 g/mol

Butone Melting Point

105 oC

Butone H2O Solubility

47.5 mg/L

Butone State

Solid

Butone LogP

4.214

Butone Dosage Forms

Bolus; Liquid; Paste; Powder; Solution; Tablet

Butone Indication

For the treatment of backache and ankylosing spondylitis

Butone Pharmacology

Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation

Butone Absorption

No information avaliable

Butone side effects and Toxicity

Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)

Butone Patient Information

No information avaliable

Butone Organisms Affected

Humans and other mammals