Phenylen
Phenylen Brand names, Phenylen Analogs
- Athrombon
- Bindan
- Cronodione
- Danedion
- Danilon
- Danilone
- Diadilan
- Dindevan
- Dineval
- Diophindane
- Emandion
- Emandione
- Eridione
- Fenhydren
- Fenilin
- Fenindion
- Hedulin
- Hemolidione
- Indema
- Indion
- Indon
- PID
- Phenhydren
- Phenillin
- Phenylen
- Phenylin
- Phenylindanedione
- Phenylindione
- Phenyline
- Phenyllin
- Pindione
- Rectadione
- Theradione
- Thrombasal
- Tromazal
- Trombol
Phenylen Brand Names Mixture
- No information avaliable
Phenylen Chemical_Formula
C15H10O2
Phenylen RX_link
No information avaliable
Phenylen fda sheet
Phenylen msds (material safety sheet)
Phenylen Synthesis Reference
No information avaliable
Phenylen Molecular Weight
222.239 g/mol
Phenylen Melting Point
148-151 oC
Phenylen H2O Solubility
27 mg/L (at 20 oC)
Phenylen State
Solid
Phenylen LogP
2.917
Phenylen Dosage Forms
Tablet
Phenylen Indication
For the treatment of pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, mural thrombosis, and thrombophili. Also used for anticoagulant prophylaxis.
Phenylen Pharmacology
Phenindione thins the blood by antagonizing vitamin K which is required for the production of clotting factors in the liver. Anticoagulants such as Phenindione have no direct effect on an established thrombus, nor do they reverse ischemic tissue damage (damage caused by an inadequate blood supply to an organ or part of the body). However, once a thrombus has occurred, the goal of anticoagulant treatment is to prevent further extension of the formed clot and prevent secondary thromboembolic complications which may result in serious and possibly fatal sequelae. Phenindione has actions similar to warfarin, but it is now rarely employed because of its higer incidence of severe adverse effects.
Phenylen Absorption
Absorbed slowly from the gastrointestinal tract.
Phenylen side effects and Toxicity
Oral, mouse: LD50 = 175 mg/kg; Oral, rat: LD50 = 163 mg/kg.
Phenylen Patient Information
No information avaliable
Phenylen Organisms Affected
Humans and other mammals
