Phenylindanedione
Phenylindanedione Brand names, Phenylindanedione Analogs
- Athrombon
- Bindan
- Cronodione
- Danedion
- Danilon
- Danilone
- Diadilan
- Dindevan
- Dineval
- Diophindane
- Emandion
- Emandione
- Eridione
- Fenhydren
- Fenilin
- Fenindion
- Hedulin
- Hemolidione
- Indema
- Indion
- Indon
- PID
- Phenhydren
- Phenillin
- Phenylen
- Phenylin
- Phenylindanedione
- Phenylindione
- Phenyline
- Phenyllin
- Pindione
- Rectadione
- Theradione
- Thrombasal
- Tromazal
- Trombol
Phenylindanedione Brand Names Mixture
- No information avaliable
Phenylindanedione Chemical_Formula
C15H10O2
Phenylindanedione RX_link
No information avaliable
Phenylindanedione fda sheet
Phenylindanedione msds (material safety sheet)
Phenylindanedione Synthesis Reference
No information avaliable
Phenylindanedione Molecular Weight
222.239 g/mol
Phenylindanedione Melting Point
148-151 oC
Phenylindanedione H2O Solubility
27 mg/L (at 20 oC)
Phenylindanedione State
Solid
Phenylindanedione LogP
2.917
Phenylindanedione Dosage Forms
Tablet
Phenylindanedione Indication
For the treatment of pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, mural thrombosis, and thrombophili. Also used for anticoagulant prophylaxis.
Phenylindanedione Pharmacology
Phenindione thins the blood by antagonizing vitamin K which is required for the production of clotting factors in the liver. Anticoagulants such as Phenindione have no direct effect on an established thrombus, nor do they reverse ischemic tissue damage (damage caused by an inadequate blood supply to an organ or part of the body). However, once a thrombus has occurred, the goal of anticoagulant treatment is to prevent further extension of the formed clot and prevent secondary thromboembolic complications which may result in serious and possibly fatal sequelae. Phenindione has actions similar to warfarin, but it is now rarely employed because of its higer incidence of severe adverse effects.
Phenylindanedione Absorption
Absorbed slowly from the gastrointestinal tract.
Phenylindanedione side effects and Toxicity
Oral, mouse: LD50 = 175 mg/kg; Oral, rat: LD50 = 163 mg/kg.
Phenylindanedione Patient Information
No information avaliable
Phenylindanedione Organisms Affected
Humans and other mammals
