PharmacyCodes



Phenylindanedione en es it fr

Phenylindanedione Brand names, Phenylindanedione Analogs

Phenylindanedione Brand Names Mixture

  • No information avaliable

Phenylindanedione Chemical_Formula

C15H10O2

Phenylindanedione RX_link

No information avaliable

Phenylindanedione fda sheet

Phenylindanedione msds (material safety sheet)

Phenylindanedione MSDS

Phenylindanedione Synthesis Reference

No information avaliable

Phenylindanedione Molecular Weight

222.239 g/mol

Phenylindanedione Melting Point

148-151 oC

Phenylindanedione H2O Solubility

27 mg/L (at 20 oC)

Phenylindanedione State

Solid

Phenylindanedione LogP

2.917

Phenylindanedione Dosage Forms

Tablet

Phenylindanedione Indication

For the treatment of pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, mural thrombosis, and thrombophili. Also used for anticoagulant prophylaxis.

Phenylindanedione Pharmacology

Phenindione thins the blood by antagonizing vitamin K which is required for the production of clotting factors in the liver. Anticoagulants such as Phenindione have no direct effect on an established thrombus, nor do they reverse ischemic tissue damage (damage caused by an inadequate blood supply to an organ or part of the body). However, once a thrombus has occurred, the goal of anticoagulant treatment is to prevent further extension of the formed clot and prevent secondary thromboembolic complications which may result in serious and possibly fatal sequelae. Phenindione has actions similar to warfarin, but it is now rarely employed because of its higer incidence of severe adverse effects.

Phenylindanedione Absorption

Absorbed slowly from the gastrointestinal tract.

Phenylindanedione side effects and Toxicity

Oral, mouse: LD50 = 175 mg/kg; Oral, rat: LD50 = 163 mg/kg.

Phenylindanedione Patient Information

No information avaliable

Phenylindanedione Organisms Affected

Humans and other mammals