Fenindion
Fenindion Brand names, Fenindion Analogs
- Athrombon
- Bindan
- Cronodione
- Danedion
- Danilon
- Danilone
- Diadilan
- Dindevan
- Dineval
- Diophindane
- Emandion
- Emandione
- Eridione
- Fenhydren
- Fenilin
- Fenindion
- Hedulin
- Hemolidione
- Indema
- Indion
- Indon
- PID
- Phenhydren
- Phenillin
- Phenylen
- Phenylin
- Phenylindanedione
- Phenylindione
- Phenyline
- Phenyllin
- Pindione
- Rectadione
- Theradione
- Thrombasal
- Tromazal
- Trombol
Fenindion Brand Names Mixture
- No information avaliable
Fenindion Chemical_Formula
C15H10O2
Fenindion RX_link
No information avaliable
Fenindion fda sheet
Fenindion msds (material safety sheet)
Fenindion Synthesis Reference
No information avaliable
Fenindion Molecular Weight
222.239 g/mol
Fenindion Melting Point
148-151 oC
Fenindion H2O Solubility
27 mg/L (at 20 oC)
Fenindion State
Solid
Fenindion LogP
2.917
Fenindion Dosage Forms
Tablet
Fenindion Indication
For the treatment of pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, mural thrombosis, and thrombophili. Also used for anticoagulant prophylaxis.
Fenindion Pharmacology
Phenindione thins the blood by antagonizing vitamin K which is required for the production of clotting factors in the liver. Anticoagulants such as Phenindione have no direct effect on an established thrombus, nor do they reverse ischemic tissue damage (damage caused by an inadequate blood supply to an organ or part of the body). However, once a thrombus has occurred, the goal of anticoagulant treatment is to prevent further extension of the formed clot and prevent secondary thromboembolic complications which may result in serious and possibly fatal sequelae. Phenindione has actions similar to warfarin, but it is now rarely employed because of its higer incidence of severe adverse effects.
Fenindion Absorption
Absorbed slowly from the gastrointestinal tract.
Fenindion side effects and Toxicity
Oral, mouse: LD50 = 175 mg/kg; Oral, rat: LD50 = 163 mg/kg.
Fenindion Patient Information
No information avaliable
Fenindion Organisms Affected
Humans and other mammals
