Rectadione
Rectadione Brand names, Rectadione Analogs
- Athrombon
- Bindan
- Cronodione
- Danedion
- Danilon
- Danilone
- Diadilan
- Dindevan
- Dineval
- Diophindane
- Emandion
- Emandione
- Eridione
- Fenhydren
- Fenilin
- Fenindion
- Hedulin
- Hemolidione
- Indema
- Indion
- Indon
- PID
- Phenhydren
- Phenillin
- Phenylen
- Phenylin
- Phenylindanedione
- Phenylindione
- Phenyline
- Phenyllin
- Pindione
- Rectadione
- Theradione
- Thrombasal
- Tromazal
- Trombol
Rectadione Brand Names Mixture
- No information avaliable
Rectadione Chemical_Formula
C15H10O2
Rectadione RX_link
No information avaliable
Rectadione fda sheet
Rectadione msds (material safety sheet)
Rectadione Synthesis Reference
No information avaliable
Rectadione Molecular Weight
222.239 g/mol
Rectadione Melting Point
148-151 oC
Rectadione H2O Solubility
27 mg/L (at 20 oC)
Rectadione State
Solid
Rectadione LogP
2.917
Rectadione Dosage Forms
Tablet
Rectadione Indication
For the treatment of pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, mural thrombosis, and thrombophili. Also used for anticoagulant prophylaxis.
Rectadione Pharmacology
Phenindione thins the blood by antagonizing vitamin K which is required for the production of clotting factors in the liver. Anticoagulants such as Phenindione have no direct effect on an established thrombus, nor do they reverse ischemic tissue damage (damage caused by an inadequate blood supply to an organ or part of the body). However, once a thrombus has occurred, the goal of anticoagulant treatment is to prevent further extension of the formed clot and prevent secondary thromboembolic complications which may result in serious and possibly fatal sequelae. Phenindione has actions similar to warfarin, but it is now rarely employed because of its higer incidence of severe adverse effects.
Rectadione Absorption
Absorbed slowly from the gastrointestinal tract.
Rectadione side effects and Toxicity
Oral, mouse: LD50 = 175 mg/kg; Oral, rat: LD50 = 163 mg/kg.
Rectadione Patient Information
No information avaliable
Rectadione Organisms Affected
Humans and other mammals
