Cronodione
Cronodione Brand names, Cronodione Analogs
- Athrombon
- Bindan
- Cronodione
- Danedion
- Danilon
- Danilone
- Diadilan
- Dindevan
- Dineval
- Diophindane
- Emandion
- Emandione
- Eridione
- Fenhydren
- Fenilin
- Fenindion
- Hedulin
- Hemolidione
- Indema
- Indion
- Indon
- PID
- Phenhydren
- Phenillin
- Phenylen
- Phenylin
- Phenylindanedione
- Phenylindione
- Phenyline
- Phenyllin
- Pindione
- Rectadione
- Theradione
- Thrombasal
- Tromazal
- Trombol
Cronodione Brand Names Mixture
- No information avaliable
Cronodione Chemical_Formula
C15H10O2
Cronodione RX_link
No information avaliable
Cronodione fda sheet
Cronodione msds (material safety sheet)
Cronodione Synthesis Reference
No information avaliable
Cronodione Molecular Weight
222.239 g/mol
Cronodione Melting Point
148-151 oC
Cronodione H2O Solubility
27 mg/L (at 20 oC)
Cronodione State
Solid
Cronodione LogP
2.917
Cronodione Dosage Forms
Tablet
Cronodione Indication
For the treatment of pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, mural thrombosis, and thrombophili. Also used for anticoagulant prophylaxis.
Cronodione Pharmacology
Phenindione thins the blood by antagonizing vitamin K which is required for the production of clotting factors in the liver. Anticoagulants such as Phenindione have no direct effect on an established thrombus, nor do they reverse ischemic tissue damage (damage caused by an inadequate blood supply to an organ or part of the body). However, once a thrombus has occurred, the goal of anticoagulant treatment is to prevent further extension of the formed clot and prevent secondary thromboembolic complications which may result in serious and possibly fatal sequelae. Phenindione has actions similar to warfarin, but it is now rarely employed because of its higer incidence of severe adverse effects.
Cronodione Absorption
Absorbed slowly from the gastrointestinal tract.
Cronodione side effects and Toxicity
Oral, mouse: LD50 = 175 mg/kg; Oral, rat: LD50 = 163 mg/kg.
Cronodione Patient Information
No information avaliable
Cronodione Organisms Affected
Humans and other mammals
