Pindione
Pindione Brand names, Pindione Analogs
- Athrombon
- Bindan
- Cronodione
- Danedion
- Danilon
- Danilone
- Diadilan
- Dindevan
- Dineval
- Diophindane
- Emandion
- Emandione
- Eridione
- Fenhydren
- Fenilin
- Fenindion
- Hedulin
- Hemolidione
- Indema
- Indion
- Indon
- PID
- Phenhydren
- Phenillin
- Phenylen
- Phenylin
- Phenylindanedione
- Phenylindione
- Phenyline
- Phenyllin
- Pindione
- Rectadione
- Theradione
- Thrombasal
- Tromazal
- Trombol
Pindione Brand Names Mixture
- No information avaliable
Pindione Chemical_Formula
C15H10O2
Pindione RX_link
No information avaliable
Pindione fda sheet
Pindione msds (material safety sheet)
Pindione Synthesis Reference
No information avaliable
Pindione Molecular Weight
222.239 g/mol
Pindione Melting Point
148-151 oC
Pindione H2O Solubility
27 mg/L (at 20 oC)
Pindione State
Solid
Pindione LogP
2.917
Pindione Dosage Forms
Tablet
Pindione Indication
For the treatment of pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, mural thrombosis, and thrombophili. Also used for anticoagulant prophylaxis.
Pindione Pharmacology
Phenindione thins the blood by antagonizing vitamin K which is required for the production of clotting factors in the liver. Anticoagulants such as Phenindione have no direct effect on an established thrombus, nor do they reverse ischemic tissue damage (damage caused by an inadequate blood supply to an organ or part of the body). However, once a thrombus has occurred, the goal of anticoagulant treatment is to prevent further extension of the formed clot and prevent secondary thromboembolic complications which may result in serious and possibly fatal sequelae. Phenindione has actions similar to warfarin, but it is now rarely employed because of its higer incidence of severe adverse effects.
Pindione Absorption
Absorbed slowly from the gastrointestinal tract.
Pindione side effects and Toxicity
Oral, mouse: LD50 = 175 mg/kg; Oral, rat: LD50 = 163 mg/kg.
Pindione Patient Information
No information avaliable
Pindione Organisms Affected
Humans and other mammals
