Tromazal
Tromazal Brand names, Tromazal Analogs
- Athrombon
- Bindan
- Cronodione
- Danedion
- Danilon
- Danilone
- Diadilan
- Dindevan
- Dineval
- Diophindane
- Emandion
- Emandione
- Eridione
- Fenhydren
- Fenilin
- Fenindion
- Hedulin
- Hemolidione
- Indema
- Indion
- Indon
- PID
- Phenhydren
- Phenillin
- Phenylen
- Phenylin
- Phenylindanedione
- Phenylindione
- Phenyline
- Phenyllin
- Pindione
- Rectadione
- Theradione
- Thrombasal
- Tromazal
- Trombol
Tromazal Brand Names Mixture
- No information avaliable
Tromazal Chemical_Formula
C15H10O2
Tromazal RX_link
No information avaliable
Tromazal fda sheet
Tromazal msds (material safety sheet)
Tromazal Synthesis Reference
No information avaliable
Tromazal Molecular Weight
222.239 g/mol
Tromazal Melting Point
148-151 oC
Tromazal H2O Solubility
27 mg/L (at 20 oC)
Tromazal State
Solid
Tromazal LogP
2.917
Tromazal Dosage Forms
Tablet
Tromazal Indication
For the treatment of pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, mural thrombosis, and thrombophili. Also used for anticoagulant prophylaxis.
Tromazal Pharmacology
Phenindione thins the blood by antagonizing vitamin K which is required for the production of clotting factors in the liver. Anticoagulants such as Phenindione have no direct effect on an established thrombus, nor do they reverse ischemic tissue damage (damage caused by an inadequate blood supply to an organ or part of the body). However, once a thrombus has occurred, the goal of anticoagulant treatment is to prevent further extension of the formed clot and prevent secondary thromboembolic complications which may result in serious and possibly fatal sequelae. Phenindione has actions similar to warfarin, but it is now rarely employed because of its higer incidence of severe adverse effects.
Tromazal Absorption
Absorbed slowly from the gastrointestinal tract.
Tromazal side effects and Toxicity
Oral, mouse: LD50 = 175 mg/kg; Oral, rat: LD50 = 163 mg/kg.
Tromazal Patient Information
No information avaliable
Tromazal Organisms Affected
Humans and other mammals
