Fenilin
Brand names,
Fenilin
Analogs
Fenilin
Brand Names Mixture
Fenilin
Chemical_Formula
C15H10O2
Fenilin
RX_link
No information avaliable
Fenilin
fda sheet
Fenilin
msds (material safety sheet)
Fenilin
Synthesis Reference
No information avaliable
Fenilin
Molecular Weight
222.239 g/mol
Fenilin
Melting Point
148-151 oC
Fenilin
H2O Solubility
27 mg/L (at 20 oC)
Fenilin
State
Solid
Fenilin
LogP
2.917
Fenilin
Dosage Forms
Tablet
Fenilin
Indication
For the treatment of pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, mural thrombosis, and thrombophili. Also used for anticoagulant prophylaxis.
Fenilin
Pharmacology
Phenindione thins the blood by antagonizing vitamin K which is required for the production of clotting factors in the liver. Anticoagulants such as Phenindione have no direct effect on an established thrombus, nor do they reverse ischemic tissue damage (damage caused by an inadequate blood supply to an organ or part of the body). However, once a thrombus has occurred, the goal of anticoagulant treatment is to prevent further extension of the formed clot and prevent secondary thromboembolic complications which may result in serious and possibly fatal sequelae. Phenindione has actions similar to warfarin, but it is now rarely employed because of its higer incidence of severe adverse effects.
Fenilin
Absorption
Absorbed slowly from the gastrointestinal tract.
Fenilin
side effects and Toxicity
Oral, mouse: LD50 = 175 mg/kg; Oral, rat: LD50 = 163 mg/kg.
Fenilin
Patient Information
No information avaliable
Fenilin
Organisms Affected
Humans and other mammals